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36 series

The Primal Hunter

Zogarth

S+97/100
On just another normal Monday, the world changed. The universe reached a threshold humanity didn't even know existed, and it was time to finally be integrated into the vast multiverse — a place where power is the only thing anyone can truly rely on. Jake, a seemingly average office worker, finds himself thrust into a tutorial filled with dangers and opportunities. In a world that should breed fear and concern, an environment that makes his fellow coworkers falter, Jake instead finds himself thriving. Perhaps Jake was born for this kind of world.
pf7.0· 1Royal Road4.65· 13KGoodreads4.50· 22.8K
AlchemyAnti-heroBase BuildingDungeon CrawlingGameLitLitRPG+6

Unintended Cultivator

Eric Dontigney

S+95/100
Sen never dreamed of ascension. Such aspirations belonged to the rich young nobles, not orphans like him scraping a living on the streets of Orchard's Reach. But when destiny takes an unexpected turn, Sen is chosen over those same nobles and adopted into a makeshift family of three ancient cultivators. These old monsters will teach him everything — from the art of the jian and spear to arcane alchemy. Yet on the path to defying the heavens, Sen must decide what kind of person he wants to be, because when his training ends, he will have formidable enemies determined to put him back in his place.
Goodreads4.55· 5.5K
AlchemyCultivationSecondary WorldWeak to StrongWuxia

Mark of the Fool

J.M. Clarke (U Juggernaut)

S+93/100
After his parents died, Alex Roth had one plan: become a wizard. Through hard work he earned a place at Generasi, the world's greatest university of wizardry. Then fate intervened—on his eighteenth birthday he is Marked as one of his kingdom's five Heroes, chosen to fight the Ravener. His brand is "The Fool," the worst of the marks. Rather than die or serve the other Heroes, Alex takes his little sister, his childhood friend, and her cerberus, and flees for the university. There he hopes to find refuge, study magic, and unravel the truth about his land's great evil. The only complication: the Mark prevents him from learning and casting spells—unless he can learn to exploit the hell out of it.
pf7.0· 1Royal Road4.60· 4.9KGoodreads4.45· 10.8K
AlchemyComedyGameLitGenius MCMysteryOverpowered MC+3

Towerbound

Samson Chui

S+90/100
Ren Varrow was never the hero type — a quiet alchemist who kept his head low while others chased glory. But when a top guild lured him into a lethal dungeon and stabbed him in the back, his story should have ended. Instead, it rewound. Thrown back to Day One, before the Tower rose and before the betrayals, Ren knows what's coming: secret quests, hidden mechanics, and a ticking clock that ends with Earth's destruction. Armed with future knowledge, he's ready to rewrite everything — from building a guild out of nobodies to crafting mythic-grade potions to surviving a hundred deadly floors.
Goodreads4.52· 1.6K
AlchemyAnti-heroBase BuildingCraftingLitRPGRegression+1

Mad Master Alchemist

Seth Ring

S89/100
Alphonso Richt is an expert botanist and genius chemist who recently burned down his lab — and lost his job along with it. Given the chance to blow off steam in Nova Terra, a cutting-edge game still in beta, Alph discovers Alchemy: a field that lets him bring his unique scientific insights to bear on the wonders of magic. Best of all, nobody minds if his potions explode.
Goodreads4.55· 882
AlchemyCompetent MCGameLitVRMMO

Divine Apostasy

A.F. Kay

S87/100
On his Ascension Day, Ruwen dies for the first time. His revived body can now learn Spells and Abilities from the Class granted by the Goddess Uru, and death is no longer permanent. His high intelligence makes becoming a Mage seem inevitable — but nothing goes as planned. When a rival god tries to kill Ruwen shortly after his disastrous Ascension, survival becomes his only focus. His choices pull him into the middle of an ancient war, and he must push through the limitations of an unexpected Class to reach level five — the bare minimum needed to have a chance.
Goodreads4.46· 4.8K
AlchemyClass SystemCultivationLitRPGSecondary WorldStats+1

Rise of the Cheat Potion Maker

Alvin Atwater

A83/100
Summoned to another world and asked to be a great hero, the protagonist wants none of it — the world already has a hero. Instead, he chooses the simplest class available: Potion Maker. He has no interest in defying the heavens or cultivating mana. But the nearby town is suffering from crippling inflation and losing businesses fast. Someone has to do something about it. An unlikely potion shopkeeper and his apprentices begin building what they hope will become an S-ranked potion shop — though that turns out to be far easier said than done.
Goodreads4.47· 2.5K
AlchemyBase BuildingClass SystemCraftingIsekaiMerchant

Tonic Shop at the Edge of the World

Max Vale

A83/100
Mason Curacao is a big dreamer with an even bigger legacy to uphold. After the unexpected deaths of his famous Alchemist parents, it's been a long, lonely summer for the new Alchemy Academy graduate. When it's finally time to open his very own Tonic Shop, the Brewmasters' Guild assigns him — the son of the famous Curacaos and top of his graduating class — to a shop located in the absolute last place anyone would ever want to travel: the Edge of the World. Despite wild and downright unsettling neighbors, Mason is determined to do his parents justice, defy the Brewmasters' Guild, and build the best damn Tonic Shop at the Edge of the World. Just as long as he doesn't fall off the Edge first.
Goodreads4.52· 485
AlchemyCozyCraftingMerchantSecondary World

Elemental Gatherers

Chris Vines

A83/100
Just one semester until graduation, a young man dies saving a little girl — only to wake up in another world, in the body of Kupiec Aiden, chosen by a deity to save the realm of Zemia. Unlike the isekai stories he's read, he retains none of Aiden's memories and must learn everything from scratch. When his exceptional innate talent for Aether Gathering is discovered, he earns a scholarship to Azyl Academy, the city's premier institution. Now he must figure out where he fits in this world — and how he's supposed to be the key to saving it.
Goodreads4.41· 3.5K
AlchemyCultivationIsekaiLitRPGSchoolTransmigration+1

Between Beast And Buddha: A Drunken Monkey's Journey to Immortality

Turniper

A82/100
Orange-crest is a monkey with simple desires: warm summer days lazing with his siblings, sampling the variety of fruit and grubs Mount Yuelu provides. Unlike his brothers, he is endlessly curious — and no subject arouses that curiosity more than the mysteries of fermentation. One fateful night, he finds himself enjoying an experimental brew far more potent than usual. Daoist Scouring Medicine is a man disgraced, caught between his uncompromising vision for pill refining and the politics of a world that discards its ideals the moment they stand in the way of profit. He wanders the slopes of an unfamiliar mountain, hitting the gourd harder than any self-respecting daoist should. From a pair of poorly considered drunken decisions, a sequence of events is set into motion that will one day shake the very heavens.
Royal Road4.81· 409
AlchemyAnti-heroComedyCultivationNon-human MCWuxia

Emberscale Alchemist

Maikana

A80/100
Born into the underground civilization of Emberscale Caverns, Kori is not your average young Kobold. She would much rather ponder life and magic than wrestle or roughhouse with her many siblings. Learning early that if she wants to know something she has to ask questions — often repeatedly — her insatiable curiosity will shape the path she walks. Follow Kori's slow progression from a curious hatchling to a productive member of Clan Emberscale, as she gradually uncovers the various facets of the world's system and finds her path to becoming something her clan has never seen before: an alchemist.
Royal Road4.78· 357
AlchemyCozyLitRPGNon-human MCSecondary WorldStats+1

The Lone Wanderer

PathOfPen

A79/100
Percy was born with little hope of standing out — just another face in a world ruled by bloodlines and class, starting with the lowest Red core and mocked as a waste. When his bloodline awakens with the power to send clones across worlds, he seizes the chance to shatter those expectations. Exploring strange realms full of danger, Percy returns with divine techniques, obscure knowledge, and treasures stolen from advanced civilizations. But mastering alchemy, outmaneuvering scheming Great Houses, and surviving invading gods will test whether a so-called waste can truly reach the stars.
Royal Road4.48· 3.3K
AlchemyCraftingCultivationGameLitIsekaiLitRPG+6

The Lone Wanderer

K. Georgiades aka PathofPen

A79/100
Percy was born with little hope of standing out — just another face in a world ruled by bloodlines and class, starting with the lowest Red core and scorned as a waste. But when his bloodline awakens with the power to send clones across worlds, he seizes the chance to shatter expectations. Exploring strange realms, Percy returns with divine techniques, obscure knowledge, and even the seed of a second mana core stolen from an advanced civilization. The elixirs he needs to advance require mastering alchemy himself — and the Great Houses, scheming titans, and invading gods will do anything to crush him before he can prove that even a so-called waste can reach the stars.
Goodreads4.46· 1.3K
AlchemyCultivationIsekaiLitRPGSecondary WorldSkill Collection+1

Qi=MC^2)

Krazekode

B70/100
Lu Jie woke up in a world filled with scheming sects, arrogant young masters, and the mad chase for the immortal heavens. He wanted none of it, and soon finds himself beaten bloody in a spar he didn't remember and treated as less than worthless. But his plan to escape the sect is interrupted by an old Alchemist's pills that heal him within moments. These medicines ignite the flame of curiosity to learn true magic in him, rekindling his love of discovery. Lu Jie sets out to study the immutable truths hidden within the world, and soon finds an all-new path of cultivation that could take him to the very top. Time to make some drugs... err... "alchemy pills."
Goodreads4.25· 2.1K
AlchemyCultivationMonster TamingWeak to Strong

Roverpowered

Drew Hayes

B69/100
Wanda is an aspiring alchemist without training, resources, or a home to return to. Her one-eyed hound Wumble is no ordinary dog — contained within him is a power many factions are actively hunting, a seed of unfathomable potential waiting to sprout. The two bond as wizard and familiar and set out to forge their own path in a dangerous world, where even furthering an alchemy education swiftly becomes a harrowing ordeal. Anyone who trifles with Wumble's wizard is in for a ruff time.
Goodreads4.40· 1.6K
AlchemyCozyMonster TamingSecondary WorldSoft MagicWholesome

Pandora Unchained

Patrick Laplante

B66/100
When Sorin's parents die under mysterious circumstances, he begs Hope — the Eighth Evil — for help, and receives an answer he never expected: he is made a Poison Cultivator, a rare class shunned by high society. Unable to continue his medical practice, he turns to adventuring with a ragtag crew: an armored polar bear, a stern archer, a sleep-deprived pyromancer, a peeping-tom rogue, and a rebellious rat familiar who won't stop eating the party's loot. When Sorin uncovers his ancestor's hidden research notes on forbidden medicine, he must discover what dark deeds his family was involved in — if he and his companions can survive the coming Demon Tide.
Goodreads4.44· 254
AlchemyClass SystemCompetent MCCultivationDungeon CrawlingSecondary World

Infernal Investigations

saithorthepyro

B66/100
Malvia was once an Infernal of the Black Flame gang, a member of the Empire's most despised race serving in one of its most infamous criminal enterprises. But that's all in the past now. One faked death later, she's been living as Katheryn Falara, a slightly sketchy alchemist operating under the nose of the law — and business is booming. With the Anglean Empire's nobility constantly scheming against each other, both magic and machine benefiting from her skills, and an ever-expanding kingdom full of rare ingredients, Malvia has been content to sit on the sidelines and make a tidy sum of cash. However, a rash of poisonings among the noble heirs makes her behind-the-scenes role impossible. Elements of a life she wanted to leave behind keep resurfacing, and soon she'll find herself at the center of a web of intrigue — figure out the web, or be trapped by it forever.
Royal Road4.68· 347
AlchemyAnti-heroMysteryNon-human MCSecondary WorldUrban Fantasy

The Way Ahead

NorskDaedalus

B66/100
Edwin never really felt many connections to other people, but as a physics student, that was fine. He was content to peel back the mysteries of the universe — though modern-day research was too well-trodden for any single enthusiast to make real headway. That doesn't apply to other worlds. Not ones where magic and Skills run rampant, where well-defined roles and Classes dominate society with little room for novel experimentation. That kind of world would be perfect for an overeager, newly-minted Alchemist to make his mark. A slice-of-life progression fantasy following someone trying to find his place in a world that doesn't know what to do with him. Expect lots of science, lots of alchemy, a few sarcastic quips from the System, and plenty of exploration.
Royal Road4.23· 1.9KGoodreads3.73· 468
AlchemyCraftingGameLitGenius MCIsekaiLitRPG+3

Wage Slave to Archmage

Mike Blackmoor

B65/100
Finn was a Senior Engineer at Google. He died at his desk at 3 AM and woke up penniless in the gutter of Cinderhold — a brutal world where humanity sits at the bottom of the food chain. His magic talent is non-existent. His mana is pathetic. Then the System loads, giving him the Genesis Editor: a tool that lets him optimize spells the way a programmer debugs code. But the System isn't free — it runs on money. To survive Abyssal horrors and corrupt mages, Finn needs gold, and he'll brew black-market tonics and exploit dungeon glitches to get it. They call it cheating. He calls it a feature.
Goodreads4.39· 924
AlchemyDungeon CrawlingIsekaiLitRPGStatsWeak to Strong

The Alchemist

Roman Romanovich

B64/100
What if you were born into a world where a game arrived thousands of years before you — and you were among the survivors of the bloody struggle that followed? Tailyn Vlashich is a young nobody far removed from those grander concerns. All he cares about is making his way through a harsh world where the emperor, powerful enemies, and an impartial god hold sway — a god that demands all things be done in accordance with its divine will. Follow Tailyn as he discovers his talent for alchemy and navigates a world that seems determined to test him at every turn.
Goodreads4.20· 1.7K
AlchemyGenius MCLitRPGSchoolSecondary WorldWeak to Strong